Premature ejaculation is the most common male sexual dysfunctionn. Existing treatments for premature ejaculation rely mostly on pharmacotherapy. Oral therapies include antidepressant drugs, which are mainly prescribed off-label. These drugs have limited efficacy and are associated with systemic side effects, such as headaches and nausea, as well as sexual side effects, such as diminished libido.
Another alternative is topical therapy, i.e. the application of desensitizing agents. This treatment method also offers limited efficacy, along with side effects such as diminished spontaneity and transvaginal absorption resulting in vaginal numbness.
There is still no effective treatment for premature ejaculation.